Sinteza mefedrona (4-MMC); enostavna izvedba - visok izkoristek

[tucoXxX]

želim skoraj 1 kg končnega izdelka. ali lahko naredim 3x večjo količino reagentov?

 

[olduser]

bolje je vzeti x4 : 2Kg bromoketona, nekateri ljudje ne dosežejo niti 50 % izkoristka + če ga želite v obliki kristalov, se vaš izkoristek zmanjša

 

[w2x3f5]

ni dovolj topila, 2,5 ure je preveč in temperatura previsoka, snov se je po dodajanju kisline izkazala za zelo umazano.

 

[SonicNL]

Temperatura in čas sta primerna. Gotovo ste se zmotili.

 

[ghostimage]

28-32с, 1h40min, full reaction so i agree with you, i am a bulk manufacturer, make minimum of 15kgs in one turn, so this parameters cost me about a year of experiments, and you here give it to people, who just dont belive you....ahahahah what a lol ;(

 

[HerrHaber]

Pred kratkim sem dosegel večji kot slišan izkoristek 4MMC hidroklorida v trenutku, ko sem to najmanj pričakoval. Preden to objavim vsem, menim, da je potrebnih več kot le 5 serij (od 5 serij sta bili 2 zaporedni z visokim izkoristkom, nato 2, za kateri sem mislil, da jih bom izboljšal, vendar jih nisem, in še ena, ki je trojna, potrebna, da lahko to navedem). Vendar mi je zmanjkalo stvari in veselim se, da bom to popolnoma dokumentiral s slikami in vsem tem. In da me ne bi obsojali zaradi zadrževanja "dragocenih" informacij, lahko zamenjam nekaj nasprotnih podrobnosti priprave:

-mešanje je ključnega pomena (da ostaneta plasti DCM in vode v najintimnejšem stiku brez katalizatorja faznega prenosa)
-relativno dolg reakcijski čas (približno 6 do 8 ur, premor si vzamem tako, da prekinem mešanje, saj predvidevam, da se reakcija skoraj ustavi, če se plasti ločijo)
-brez segrevanja (pri tretjem in četrtem poskusu sem imel povprečne in nižje izkoristke, ko sem rahlo segreval)
-ohlajanje zmesi in reagentov (v fazi kisanja so bile ohlajene tekočine najbolj donosne)
-hitro filtriranje (takoj po obarjanju trdnih delcev, ne pustite, da ostanejo, ker bo del proizvoda prešel v raztopino)

Upam, da bo to pomagalo, in obljubim, da se bom vrnil s podrobnostmi in zakaj ne, potrditev s strani drugega aktivnega člana.

 

[mcdonalds]

hello,
i'm not sure why condenser is used in this syntessis.
is correct that is for condense methylamine gas and keep it in the reaction

 

[Naruto]

No

 

[olduser]

yes, but as methylamine is already in excess I guess it's used to reduce the smell

 

[HerrHaber]

yes, but harmful even more so

 

[William D.]

If you use cooling with liquid nitrogen, the reaction mixture in the flask would simply freeze . Therefore, only an excess that is filtered or evaporates into the atmosphere

 

[Ranbir Singh]

How can change mephedrone powder to crystel form please tell me

 

[dnBQByvHb8Zkawbjpx]

Using the process called crystallization: http://bbzzzsvqcrqtki6umym6itiixfhn...n/threads/mephedrone-4mmc-crystallization.72/

 

[agness]

Can I use a Ethyl acetate instead of Dichloromethane?

 

[olduser]

Yes

 

[lucky2222]

hello thank you for info knowledge was wonder on the sop if you had methylamine HCL instead of methylamine 40%aq what step would you use instead to make it a liquid ? thank you again for your time

 

[William D.]

@lucky2222 there is a lot of information on this forum about this. You can use water or alcohol with sodium hydroxide or triethylamine to produce gas. Triethylamine is more convenient in some cases if it is available to you.

 

[Blazey]

nice, i missed out on this chem before the bans in the uk, glad to see its around still, i wanna try it me as I love mdma

 

[lucky2222]

hello was wondering if there away to substitute methylamine 40%aq with methylamine hcl in this sop ?

 

[Rhales]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[olduser]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[Rhales]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good

 

[olduser]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good