Síntese de mefedrona (4-MMC); fácil de executar - alto rendimento

[tucoXxX]

Quero quase 1 kg de produto acabado. Posso fazer 3x a quantidade de reagentes?

 

[olduser]

é melhor tomar x4 : 2Kg de bromocetona, algumas pessoas nem sequer atingem o rendimento de 50% + se a quiser em forma de cristal, o seu rendimento diminui

 

[w2x3f5]

não há solvente suficiente, 2,5 horas é demasiado tempo e a temperatura demasiado elevada, a substância revelou-se muito suja após a adição do ácido.

 

[SonicNL]

A hora e a temperatura estão correctas. Deve ter-se enganado.

 

[ghostimage]

28-32с, 1h40min, full reaction so i agree with you, i am a bulk manufacturer, make minimum of 15kgs in one turn, so this parameters cost me about a year of experiments, and you here give it to people, who just dont belive you....ahahahah what a lol ;(

 

[HerrHaber]

Recentemente, obtive um rendimento superior ao esperado de cloridrato de 4MMC num momento em que menos esperava. Antes de o tornar público a toda a gente, acho que são necessárias mais do que apenas 5 passagens (das 5, 2 consecutivas foram de alto rendimento, depois 2 que pensei melhorar, mas não melhorei, e outra que faz o triplicado necessário para eu poder afirmar isto). No entanto, fiquei sem material e estou ansioso por documentar isto completamente com fotografias e tudo isso. E para não ser julgada por reter informações "preciosas", posso trocar alguns pormenores contra-intuitivos da preparação:

-a agitação é fundamental (para manter as camadas de DCM e água em contacto íntimo sem catalisador de transferência de fase)
-tempo de reação relativamente longo (cerca de 6 a 8h, utilizo um intervalo para parar a agitação, assumindo que, se as camadas se separarem, a reação é quase interrompida)
-sem aplicação de calor (o meu terceiro e quarto ensaios tiveram rendimentos médios e inferiores quando foi aplicado um aquecimento suave)
-arrefecimento da mistura e dos reagentes (na fase de acidificação, os líquidos arrefecidos foram os que produziram melhores resultados)
-filtrar rapidamente (logo após a precipitação dos sólidos, não deixar ficar, pois parte do produto irá para a solução)

Espero que isto ajude e prometo voltar com detalhes e, porque não, uma validação de outro membro ativo.

 

[mcdonalds]

hello,
i'm not sure why condenser is used in this syntessis.
is correct that is for condense methylamine gas and keep it in the reaction

 

[Naruto]

No

 

[olduser]

yes, but as methylamine is already in excess I guess it's used to reduce the smell

 

[HerrHaber]

yes, but harmful even more so

 

[William D.]

If you use cooling with liquid nitrogen, the reaction mixture in the flask would simply freeze . Therefore, only an excess that is filtered or evaporates into the atmosphere

 

[Ranbir Singh]

How can change mephedrone powder to crystel form please tell me

 

[dnBQByvHb8Zkawbjpx]

Using the process called crystallization: http://bbzzzsvqcrqtki6umym6itiixfhn...n/threads/mephedrone-4mmc-crystallization.72/

 

[agness]

Can I use a Ethyl acetate instead of Dichloromethane?

 

[olduser]

Yes

 

[lucky2222]

hello thank you for info knowledge was wonder on the sop if you had methylamine HCL instead of methylamine 40%aq what step would you use instead to make it a liquid ? thank you again for your time

 

[William D.]

@lucky2222 there is a lot of information on this forum about this. You can use water or alcohol with sodium hydroxide or triethylamine to produce gas. Triethylamine is more convenient in some cases if it is available to you.

 

[Blazey]

nice, i missed out on this chem before the bans in the uk, glad to see its around still, i wanna try it me as I love mdma

 

[lucky2222]

hello was wondering if there away to substitute methylamine 40%aq with methylamine hcl in this sop ?

 

[Rhales]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[olduser]

Sry I don't understand clearly your question. The addition of water is used to dissolve the polar impurities in the solution after the reaction (2B4M, methylamine, etc). You need to let it a few minutes then throw away all of the water, only the oil stays.
You can addapt the protocol to 3mmc aswell, you need to use 2-bromo-3-methylpropiophenone as main reagent and keep the same molar ratio (as they are isomers, you can keep the exact same amounts).

 

[Rhales]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good

 

[olduser]

If it's your first batch, I recommend using protocols that has been written by the forum experts. These are good too but hasn't always been tested and are more about experimentation once you already know the synth. WillD threads about mephedrone are really good