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Full MDP2NP synthesis from natural piperine. Stage 1: piperonal synthesis from piperine.
So with this method with THF and potassium permanganate ...



Swim could use the piperine (from black pepper extract <95% pure piperine)

straight as is ?



Or



Convert the piperine to piperic acid (as usual, by reacting it with a hydroxide such as potassium hydroxide, then acidifying the formed piperate salt with hydrochloric acid or another acid.)

And then use the piperic acid with the THF and potassium permanganate method ?



To get the good yeilds of piperonal



?
 

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Synthesis of Amphetamines (Phenylethylamines)
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