SGT-263 (CUMYL-5F-P7AICA)

[William D.]

Reaction scheme:

Synthesis:
1. A solution of 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol), oxalyl chloride (0.6 mL, 7.2 mmol), and DMF (1 mL) in dichloromethane (20 mL) was stirred for 20 min.
2. The mixture was evaporated and then redissolved in methanol (20 mL) and stirred for 40 min.
3. The mixture was evaporated and then extracted with ethyl acetate.
4. The organic phase was washed with saturated sodium bicarbonate solution and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.36 g, 68%).
5. A solution of Step 4 (0.36 g, 2 mmol), potassium t-butoxide (0.27 g, 2.4 mmol), and 1-bromo-5-fluoropentane (1.6 g,9.5 mmol) in THF (20 mL) was stirred for 24 h.
6. The mixture was extracted with ethyl acetate.
7. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo.
8. The residue was purified by silica gel chromatography with stepwise gradient elution of n-hexane/ethyl acetate (3:1–2:1–1:1, v/v) to yield the white solid (0.35 g, 65%).
9. A solution of step 8 (0.35 g, 1.3 mmol) and 6 mol/L sodium hydroxide solution (10 mL) in methanol/THF (2:1,v/v, 15 mL) was stirred for 1.5 days.
10. The mixture was evaporated, added to water, and then washed with ethyl acetate.
11. A solution of 1 mol/L hydrochloric acid was added to the aqueous phase, and the mixture was extracted with ethyl acetate.
12. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.39 g, quant.)
13. A solution of step 12 (0.39 g, 1.3 mmol), oxalyl chloride (3 mmol), and DMF (1 mL) in dichloromethane (12 mL) was stirred for 10 min.
14. The mixture was evaporated and then redissolved in dichloromethane (10 mL).
15. Cumylamine (2 mmol) and triethylamine (0.5 mL) were added to the solution and stirred for 15 h.
16. The mixture was evaporated and then extracted with ethyl acetate.
17. The organic phase was washed with 0.1 mol/L hydrochloric acid solution, saturated sodium bicarbonate solution and brine, and then dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.37 g, 77%).​

 

[onionexpress]

Liels paldies ! Vai varat man sniegt proporcijas 1 kg gala produkta ?

 

[MuricanSpirit]

Vienkārši reiziniet visu ar 370x (1000g/0,37g = 370 attiecība) kā "pamatnoteikumu".

Protams, esmu pārliecināts, ka daži šķīdinātāji pieļauj lielāku maisījuma blīvumu, piem., jums nevajadzēs 370x vairāk etilacetāta, bet jūs ātri pamanīsiet, kad šķīdums ir pārsātināts, bet paturiet prātā, ka lielāks siltums pieļauj lielāku piesātinājumu (nezinu, kāpēc).

 

[onionexpress]

Paldies par to, ka es to novērtēju. Bet im jaunpienācējs, un man ir nepieciešama specifiska informācija, lai izvairītos no kļūdām.

 

[onionexpress]

Vai kāds var augšupielādēt mācību video? Es esmu iesācējs, un man nav jāzina katrs solis (tostarp nepieciešamais aprīkojums). Būtu pateicīgs, liels paldies.

 

[William D.]

in PM

 

[00000000]

can u send me to pls Paldies.

 

[BackstagePanther]

Sveiki, vai šis ir analogs 5F-ĶUMIL-PEGAKLONAM (5F-SGT-151) ?
Vai plānojat augšupielādēt arī tā sintēzi? Tas būtu vairāk nekā interesanti.
Paldies par jūsu milzīgo darbu.

 

[G.Patton]

Tam ir atšķirīgs oglekļa skelets

 

[BackstagePanther]

Ak, es tikko sapratu, ka 5F-SGT-151 bāze satur un veselu 3. benzola gredzenu. Nomenklatūras augšupielāde.
Bija jautājums, vai 5F-SGT-151 varētu izgatavot un tā vietā 1-brom-5-fluoropentāna izmantot kā astes,
varētu izmantot 1-brom-6-fluorheksānu. Vai tas nodrošinātu vēl lielāku afinitāti pret receptoriem/iedarbību?

 

[G.Patton]

Saskaņā ar šiem datiem es teiktu, ka jā, bet tā ir tikai hipotēze.

 

[Lordseeds]

 

[Lordseeds]

Jā, es domāju, ka ar to pietiks. Man ir vēl viens jautājums. Kurš ir spēcīgākais kanabinoīds?

 

[William D.]

adb-chminaca un daži klasiskā tipa noīdus.

 

[king of synthesis]

Hallo,
Vai piridīns šajā reakcijā ir alternatīva kālija tercbutoksīdam?

 

[soebunies]

nav

 

[jejekororun]

I am interested in the synthesis of 5F-adb is there a simple reliable recipe?