Fastest Reduction Method?

[Blammo]

I'm just making sure my readings are correct.

It seems that borohydride and maybe mercury amalgam are the fastest reduction methods. The borohydride can take a while, but it can be cut short for some losses in yield. I bet a bit of an excess of borohydride can solve that though, any thoughts on that?

Am I correct that mercury amalgam and borohydride are probably the fastest reduction methods of ketone to amine?

 

[mewnmewamine]

I would say either or the way to increase yields with NaBH4 is to use a cupric chloride catalyst.

Red al is also rather quick

 

[Osmosis Vanderwaal]

Lithium is the strongest reducer. It can give electrons (protons) at an incredible rate. I'd expect it to be fastest due to that. I think reductions are limited by kenetics more than particular reductants. You could likely make meth in 0.001 seconds, if you can contain a serious explosion and a mountain of sideproducts

 

[Chemtrail]

Would love to have a couple hundred Gs of P2P and experiment with different reduction METHods (Al/Hg amalgam, sodium borohydride, sodium cyanoborohydride, Leukert, Aluminum Lithium Hydride AlLiH4 with THF solvent)

*There's electroreduction, hydrogenation with Pd and/or Pt metal -likes', Raney Nickel, Uresumbrella .. spelled wrong sorry



Got a couple of great references for this fine thread

SEE:

Methamphetamine and Amphetamine Syntheses Methods Comparison​

by GhostChemist

and

Erowid link

https://www.erowid.org/archive/rhodium/chemistry/amphetamine.reduction.html

Enjoy

 

[Osmosis Vanderwaal]

When I say I know 40 pathways, this is the document i plan to cite if asked for a citation. Im pretty sure there are some missing from this compilation