SGT-263 (KUMÜÜL-5F-P7AICA)

[William D.]

Reaction scheme:

Synthesis:
1. A solution of 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol), oxalyl chloride (0.6 mL, 7.2 mmol), and DMF (1 mL) in dichloromethane (20 mL) was stirred for 20 min.
2. The mixture was evaporated and then redissolved in methanol (20 mL) and stirred for 40 min.
3. The mixture was evaporated and then extracted with ethyl acetate.
4. The organic phase was washed with saturated sodium bicarbonate solution and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.36 g, 68%).
5. A solution of Step 4 (0.36 g, 2 mmol), potassium t-butoxide (0.27 g, 2.4 mmol), and 1-bromo-5-fluoropentane (1.6 g,9.5 mmol) in THF (20 mL) was stirred for 24 h.
6. The mixture was extracted with ethyl acetate.
7. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo.
8. The residue was purified by silica gel chromatography with stepwise gradient elution of n-hexane/ethyl acetate (3:1–2:1–1:1, v/v) to yield the white solid (0.35 g, 65%).
9. A solution of step 8 (0.35 g, 1.3 mmol) and 6 mol/L sodium hydroxide solution (10 mL) in methanol/THF (2:1,v/v, 15 mL) was stirred for 1.5 days.
10. The mixture was evaporated, added to water, and then washed with ethyl acetate.
11. A solution of 1 mol/L hydrochloric acid was added to the aqueous phase, and the mixture was extracted with ethyl acetate.
12. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.39 g, quant.)
13. A solution of step 12 (0.39 g, 1.3 mmol), oxalyl chloride (3 mmol), and DMF (1 mL) in dichloromethane (12 mL) was stirred for 10 min.
14. The mixture was evaporated and then redissolved in dichloromethane (10 mL).
15. Cumylamine (2 mmol) and triethylamine (0.5 mL) were added to the solution and stirred for 15 h.
16. The mixture was evaporated and then extracted with ethyl acetate.
17. The organic phase was washed with 0.1 mol/L hydrochloric acid solution, saturated sodium bicarbonate solution and brine, and then dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.37 g, 77%).​

 

[onionexpress]

Suur tänu ! Kas te saate mulle anda proportsioonid 1kg lõpptoote jaoks ?

 

[MuricanSpirit]

Lihtsalt korrutage kõike 370x (1000g/0,37g = 370 suhe) kui "põhireegel".

Loomulikult olen kindel, et mõned lahustid võimaldavad suurema tihedusega segu nt te ei vaja 370x rohkem etüülatsetaati, kuid te märkate kiiresti, kui lahus on üleküllastunud, kuid pidage meeles, et suurem soojus võimaldab rohkem küllastumist (ei ole kindel, miks).

 

[onionexpress]

Tänan selle eest, et ma hindan seda. Aga im algaja ja ma vajan konkreetset teavet, et vältida vigu.

 

[onionexpress]

Kas keegi saab üles laadida õppevideo? Ma olen algaja ja ma ei taha teada iga sammu (sealhulgas vajalikke seadmeid). Oleksin tänulik tänu palju

 

[William D.]

in PM

 

[00000000]

can u saata mulle pls aitäh.

 

[BackstagePanther]

Tere, kas see on analoog 5F-CUMYL-PEGACLONE (5F-SGT-151) ?
Kas te kavatsete ka selle sünteesi üles laadida? See oleks rohkem kui huvitav.
Tänan teid teie tohutu töö eest.

 

[G.Patton]

Sellel on erinev süsiniku skelett

 

[BackstagePanther]

Oh, ma just mõistsin, et 5F-SGT-151 alus sisaldab ja tervet 3. benseeniringi. Nomenklatuuri üleslaadimine.
Mõtlesin, kas 5F-SGT-151 võiks meisterdada ja 1-bromo-5-fluoropentaani asemel kasutada sabana,
võiks kasutada 1-bromo-6-fluorheksaani. Kas see annaks meile veelgi suurema retseptori afiinsuse / mõju?

 

[G.Patton]

Nende andmete põhjal ütleksin, et jah, kuid see on vaid hüpotees.

 

[Lordseeds]

 

[Lordseeds]

Jah, ma arvan, et sellest piisab. Mul on veel üks küsimus. Millised on kõige tugevamad kannabinoidid?

 

[William D.]

adb-chminaca ja mõned klassikalise tüüpi noidid.

 

[king of synthesis]

Hallo,
Kas püridiin on selles reaktsioonis alternatiiviks kaaliumtertbutoksiidile?

 

[soebunies]

no

 

[jejekororun]

I am interested in the synthesis of 5F-adb is there a simple reliable recipe?