SGT-263 (CUMYL-5F-P7AICA)

[William D.]

Reaction scheme:

Synthesis:
1. A solution of 1H-pyrrolo[2, 3-b]pyridine-3-carboxylic acid (0.49 g, 3 mmol), oxalyl chloride (0.6 mL, 7.2 mmol), and DMF (1 mL) in dichloromethane (20 mL) was stirred for 20 min.
2. The mixture was evaporated and then redissolved in methanol (20 mL) and stirred for 40 min.
3. The mixture was evaporated and then extracted with ethyl acetate.
4. The organic phase was washed with saturated sodium bicarbonate solution and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.36 g, 68%).
5. A solution of Step 4 (0.36 g, 2 mmol), potassium t-butoxide (0.27 g, 2.4 mmol), and 1-bromo-5-fluoropentane (1.6 g,9.5 mmol) in THF (20 mL) was stirred for 24 h.
6. The mixture was extracted with ethyl acetate.
7. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo.
8. The residue was purified by silica gel chromatography with stepwise gradient elution of n-hexane/ethyl acetate (3:1–2:1–1:1, v/v) to yield the white solid (0.35 g, 65%).
9. A solution of step 8 (0.35 g, 1.3 mmol) and 6 mol/L sodium hydroxide solution (10 mL) in methanol/THF (2:1,v/v, 15 mL) was stirred for 1.5 days.
10. The mixture was evaporated, added to water, and then washed with ethyl acetate.
11. A solution of 1 mol/L hydrochloric acid was added to the aqueous phase, and the mixture was extracted with ethyl acetate.
12. The organic phase was washed with brine and dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.39 g, quant.)
13. A solution of step 12 (0.39 g, 1.3 mmol), oxalyl chloride (3 mmol), and DMF (1 mL) in dichloromethane (12 mL) was stirred for 10 min.
14. The mixture was evaporated and then redissolved in dichloromethane (10 mL).
15. Cumylamine (2 mmol) and triethylamine (0.5 mL) were added to the solution and stirred for 15 h.
16. The mixture was evaporated and then extracted with ethyl acetate.
17. The organic phase was washed with 0.1 mol/L hydrochloric acid solution, saturated sodium bicarbonate solution and brine, and then dried with Na2SO4, and the solvent was removed in vacuo to yield the white solid (0.37 g, 77%).​

 

[onionexpress]

Mange tak skal du have! Kan du give mig proportioner for 1 kg slutprodukt?

 

[MuricanSpirit]

Bare gang alt med 370x (1000g/0,37g = 370 ratio) som "grundregel".

Selvfølgelig er jeg sikker på, at nogle opløsningsmidler tillader en blanding med højere densitet, f.eks. har du ikke brug for 370x mere ethylacetat, men du bemærker hurtigt, når opløsningen er overmættet, men husk, at mere varme tillader mere mætning (ikke sikker på hvorfor).

 

[onionexpress]

Tak for det, jeg sætter pris på det. Men jeg er nybegynder, og jeg har brug for specifikke oplysninger for at undgå fejl.

 

[onionexpress]

Kan nogen uploade en tutorial-video? Jeg er nybegynder, og jeg vil ikke kende hvert trin (inklusive nødvendigt udstyr). Jeg ville være taknemmelig, mange tak

 

[William D.]

i PM

 

[00000000]

kan du sende mig til pls tak.

 

[BackstagePanther]

Hej, er dette en analog til 5F-CUMYL-PEGACLONE (5F-SGT-151)?
Har du også tænkt dig at uploade en syntese af den? Det ville være mere end interessant.
Tak for dit enorme arbejde.

 

[G.Patton]

Det har forskellige kulstofskeletter

 

[BackstagePanther]

Åh, jeg har lige indset, at basen af 5F-SGT-151 indeholder en hel 3. benzenring. Uploader nomenklatur.
Jeg tænkte på, om 5F-SGT-151 kunne laves og i stedet for 1-brom-5-fluoropentan bruges som hale,
kunne vi bruge 1-brom-6-fluorhexan. Ville dette give os endnu større receptoraffinitet / effekter?

 

[G.Patton]

Ud fra disse data vil jeg sige ja, men det er kun en hypotese.

 

[Lordseeds]

 

[Lordseeds]

Ja, jeg tror, det er nok. Jeg har et andet spørgsmål. Hvilke cannabinoider er de stærkeste?

 

[William D.]

adb-chminaca og nogle klassiske typer noider.

 

[king of synthesis]

Hej med dig,
Er pyridin et alternativ til kalium-tert-butoxid i denne reaktion?

 

[soebunies]

nej

 

[jejekororun]

I am interested in the synthesis of 5F-adb is there a simple reliable recipe?